Also tell your doctor if you are allergic to rubber or latex. Official answer by One serious danger of taking Repatha (evolocumab) is a possibly life-threatening allergic reaction to the active ingredient. FAQ Are there any dangers of taking Repatha? Medically reviewed by Leigh Ann Anderson, PharmD.Repatha mechanism of action As an adjunct to diet, alone or in combination with other low-density lipoprotein cholesterol (LDL-C)-lowering therapies, in adults with primary hyperlipidemia, including heterozygous familial hypercholesterolemia (HeFH) to reduce LDL-C REPATHA SAFETY PROFILE Across more than 26,000 patients, Repatha demonstrated a consistent safety profile